Yes. When optimizing, set per‑route limits (max items/weight) so loads fit the assigned vehicle. You can also create Vehicle Profiles for an additional indicator for routes that have specific restrictions by vehicle, and enable route constraints (e.g., avoid tolls or U‑turns), and reuse them across routes. These settings help prevent overloads and keep route planning aligned with your real fleet.
See: Creating routes by vehicle capacity · Vehicle Profiles · Max items per route